Mexico: Klebsiella oxytoca infections linked to possible contamination of Parenteral Nutrition (NPT)
An outbreak of Klebsiella oxytoca multi-drug resistant (MDR) detected in four health care units in the State of Mexico is associated with a possible contamination of Parenteral Nutrition (TPN) or the supplies for its application.
So far, 20 cases have been identified. Unfortunately, 13 patients with co-morbidities have died and are being investigated to determine if the cause of death is related to this bacteria. Seven patients are still under medical care and their cultures are negative after treatment.
All of the identified patients are pediatric patients, in an age range from 0 to 14 years.
Since November 29, decisive actions have been taken to control this outbreak, and these actions continue. Ongoing analyses are seeking to identify the source of the outbreak, and ongoing monitoring is being maintained to rule out possible outbreaks in other entities.
In this regard, it is important to inform the population that, upon identifying that the outbreak is associated with possible contamination of parenteral nutrition or the inputs for its application, the Federal Commission for the Protection against Sanitary Risks, Cofepris, in addition to issuing a health alert for the preventive immobilization of the batches of parenteral nutrition produced by the company as of November 21, until conclusive information is available that includes the analysis of the raw materials, carried out an inspection at the mixing plant where these paraenteral nutritions were produced, concluding that no critical findings were found in said facilities.
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For its part, the Institute of Diagnosis and Epidemiological Reference (InDRE) isolated the bacteria, both in human samples and in cultures from paraenteral solutions.
Finally, the Ministry of Health, the General Directorate of Epidemiology, InDRE, Cofepris, as well as the health authorities of the government of the State of Mexico, are working in a coordinated manner to identify the origin of this outbreak. Progress in the investigations will be reported.