Uganda reports 2nd human Crimean-Congo hemorrhagic fever case of 2025
The Uganda Ministry of Health (MOH) reported a Crimean-Congo hemorrhagic fever (CCHF) in Kyegegwa district in the western part of the country.
The case is a 28-year-old male who presented with headache, general body weakness, nose bleeding and abdominal pain at Bijubuli Health Center.
CCHF virus was confirmed by PCR by the Uganda Virus Research Institute.
This is the second confirmed CCHF case reported in Uganda this year. In early January, a 45-year-old male farmer in Mubende district contracted the virus.
Cumulatively, Uganda has reported 2 confirmed cases, 3 suspected and 1 probable case in 2025 from two districts to date. No deaths have been reported.
In 2024, twenty cases (8 confirmed, 4 probable and 8 suspected cases), and four deaths were reported (40%CFR) from five districts.
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Crimean-Congo hemorrhagic fever is a widespread disease caused by a tick-borne virus (Nairovirus) of the Bunyaviridae family. The CCHF virus causes severe viral hemorrhagic fever outbreaks, with a case fatality rate of 10–40%.
Animals become infected by the bite of infected ticks and the virus remains in their bloodstream for about one week after infection, allowing the tick-animal-tick cycle to continue when another tick bites. Although a number of tick genera are capable of becoming infected with CCHF virus, ticks of the genus Hyalomma are the principal vector.
The CCHF virus is transmitted to people either by tick bites or through contact with infected animal blood or tissues during and immediately after slaughter. The majority of cases have occurred in people involved in the livestock industry, such as agricultural workers, slaughterhouse workers and veterinarians. Human-to-human transmission is possible.
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